What are the algorithms used in the block studies for optimizing the number of samples and power?
Currently the software employs methods to estimate power and sample size for standard linear regression models. Ref: Hsieh FY, Block DA, Larsen MD: A simple method of sample size calculation for linear and logistic regression. Stat Med. 1998, 17: 1623-1634. 10.1002/(SICI)1097-0258(19980730)17:14<1623::AID-SIM871>3.0.CO;2-S